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[MailScanner] now includes support for [SpamAssassin]. This is "a virus scanner for e-mail designed for use on e-mail gateways. It can also detect a large proportion of unsolicited commercial e-mail (spam) passing through it."  [MailScanner] does an excellent job with file names and types, and can be set to quarantine encrypted .ZIP files and apply normal filename rules and virus scanning inside unencrypted ones. 
\[http://www.sng.ecs.soton.ac.uk/mailscanner/\]

OpenProtect is a complete package which includes MailScanner for intergration with MTAs, spamassassin, clamav and it can be installed within 5-10 minutes and no need to manually edit any configuration files or settings. http://openprotect.com OpenProtect supports postfix, sendmail, qmail and exim. See http://wiki.apache.org/spamassassin/OpenProtect or http://openprotect.com for more details.

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Another option is to use a filtering SMTP proxy such as spampd.  It is typically used to filter the mail between an external-facing MTA instance/relay, and an "internal" MTA instance.
\[http://www.worlddesign.com/index.cfm/rd/mta/spampd.htm\]

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